α-кетоглутарик

Phcoker има можност за масовно производство и снабдување на калциум 2-оксоглутарат и алфа-кетоглутаринска киселина под услов на cGMP.

Со кои други имиња се познава алфа-кетоглутаринска киселина?

A-cétoglutarate, A-Ketoglutaric Acid, Acide XNUMX-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate d'Arginine, Alpha-Cétoglutarate de Calcium, Alpha-Cétoglutarate de Créatine, Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Keto Glutaric Acid, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alpha KG, AAKG, AKG, Arginine Alpha-Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, XNUMX-Oxoglutaric Acid, XNUMX-Oxopentanedoicic Acid.

Што е алфа-кетоглутарна киселина?

Alpha-ketoglutaric (AKG) is an organic acid that is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid cycle. It is a precursor to glutamic acid, the non-essential amino acid involved in protein synthesis and the regulation of blood glucose levels. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids. Individuals with high protein intake, bacterial infections, or gastrointestinal dysbiosis may benefit from supplemental AKG to help balance ammonia levels and protect tissues.

Some people take alpha-ketoglutarate to improve peak athletic performance. Suppliers of athletic nutritional supplements claim alpha-ketoglutaric acid may be an important addition to proper diet and training for the athlete who wants peak performance. They base this claim on studies that show extra ammonia in the body can combine with alpha-ketoglutarate to reduce problems associated with too much ammonia (ammonia toxicity). But, so far, the only studies that show alpha-ketoglutarate can reduce ammonia toxicity have been performed in hemodialysis patients.

Healthcare providers sometimes give alpha-ketoglutarate intravenously (by IV) for preventing injury to the heart caused by blood flow problems during heart surgery and for preventing muscle breakdown after surgery or trauma.

Механизмите на дејство на алфа-кетоглутаринската киселина

The exact mechanisms of action for α-Ketoglutarate have not yet been elucidated. Some of α-Ketoglutarate’s actions include acting in the Krebs cycle as an intermediate, transamination reactions during the metabolism of amino acids, forming glutamic acid by combining with ammonia, and reducing nitrogen by combining with it as well. Concerning α-Ketoglutarate’s actions with ammonia, it is proposed that α-Ketoglutarate can help patients with propionic academia who have high levels of ammonia and low levels of glutamine/glutamate in their blood. Because endogenous glutamate/glutamine is produced from α-Ketoglutarate, propionic acidemia patients have impaired production of α-Ketoglutarate and supplementation of α-Ketoglutarate should improve the condition of these patients. Several other experimental studies have also shown that administration of α-Ketoglutarate in parenteral nutrition given to post-operative patients helped attenuate the decreased synthesis of muscle protein that is often seen after a surgery. This decreased muscle synthesis is speculated to be due to too low α-Ketoglutarate levels.

Alpha ketoglutaric acid (AKG) supplement - What are the benefits of Alpha ketoglutaric acid?

Алфа-кетоглутарат (AKG) како додаток на атлетските перформанси
Alpha ketoglutaric acid, or Alpha-ketoglutarate is a product of the mitochondria and plays a vital role in the conversion of food into energy. It is also a source of glutamine and glutamate. In muscles, glutamine and glutamate inhibit protein breakdown and increase protein synthesis.

Алфа-кетоглутарат го подобрува формирањето на коските. Ја регулира синтезата на колаген евентуално со зголемување на бројот на молекули достапни за синтеза. Колагенот е значајна компонента на коскеното ткиво.

Алфа-кетоглутаратот го стимулира производството на инсулин-како фактор на раст-1 и хормон за раст. Овие двајцата се хормони кои го регулираат рециклирањето на коските и формирањето на ново коскено ткиво.

алфа кетоглутаринска киселина придобивки за стареење
Студиите покажаа дека АКГ потенцијално може да третира повеќе состојби кога се зема според упатствата.

Сепак, постојат и други индикации дека алфа-кетоглутаратот (AKG) може да помогне во својствата против стареење.

Едно големо истражување спроведено на Институтот за истражување на стареењето на Бак заедно со здравјето на Понс де Леон откриле подобрен здравствен опсег за дури 60% во нивната студија за цицачи.

α-кетоглутарик
AKG го продолжува животниот век на возрасните кај C. elegans. (А) АКГ го продолжува животниот век на возрасните црви. (Б) Крива на одговор на дозата на ефектот AKG врз долговечноста.
In addition, Ponce De Lon Health (PDL) released an experimental report, the report showing that after half a year, the physiological age of the subjects decreased on average XNUMX years old after taking the alpha-ketoglutarate (AKG) contained in the company.

Other compounds, like the antiaging drug rapamycin and the diabetes treatment metformin, have shown similar effects in mouse experiments. But AKG is naturally made by mice and by our own bodies, and it is already considered safe to consume by regulators.

The things we need to pay attention to is that pure alpha ketoglutaric acid is very acidic and not easy to eat. The fitness supplements on the market are added with arginine-α-ketoglutarate(AAKG), the main component of which is arginine, while the one used by Ponce De Lon Health is α-ketoglutarate calcium.

Alpha-ketoglutarate also has immune-enhancing properties
AKG is also called the immune nutrient factor and it play an important role in the general immune metabolism. It is already known that AKG is an important source of glutamine and glutamate, is defined as glutamine homologue and derivative . In the body, it is converted into glutamine. Glutamine can increase levels of white blood cells (macrophages and neutrophils).AKG as glutamine homologue has immuno-enhancing properties, can maintain a gut barrier, increase immune cells and the activity of neutrophils and phagocytosis, reduce bacterial translocation in vivo .

Суд:

  1. Аусел Ц, Каудреј-Лукас Ц, Ласниер Е, и др. Внесувањето на алфа-кетоглутарат кај човечки фибробласти. Cell Biol Int 1996; 20: 359-63.
  2. Wernerman J, Hammarqvist F, Vinnars E. Alpha-ketoglutarate и постоперативен мускулен катаболизам. Лансет 1990; 335: 701-3.
  3. Blomqvist BI, Hammarqvist F, von der Decken A, Wernerman J. Glutamine and alpha-ketoglutarate prevent the decrease in muscle free glutamine concentration and influence protein synthesis after total hip replacement. MetabolismXNUMX;XNUMX:XNUMX-XNUMX.
  4. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E. Alpha-ketoglutarate зачувува синтеза на протеини и слободен глутамин во скелетните мускули по операцијата. Хирургија 1991; 109: 28-36.
  5. Zhang W, Qu J, Liu GH, et al. Стареењето на епигеномот и неговото подмладување [J]. Природата ги разгледува биологијата на молекуларните клетки, 2020, 21 (3).
  6. Роадс ТВ, Андерсон Р.М. Алфа-кетоглутарат, метаболит кој го регулира стареењето кај глувците [J]. Метаболизам на клетките, 2020 година.
  7. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ.